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CeftazidiMe t-Butyl Ester

Ceftazidime t-Butyl Ester

CAS: 102772-66-7

Molecular Formula: C26H30N6O7S2

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CeftazidiMe t-Butyl Ester - Names and Identifiers

Name Ceftazidime t-Butyl Ester
Synonyms Ceftazidime EP Imp E
Ceftazidime t-Butyl Ester
Ceftazidime Ep Impurity E
CeftazidiMe t-Butyl Ester
Ceftazidime Impurity D(EP)
Ceftazidime tert-butyl ester
(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-[[2-(1,1-diMethylethoxy)-1,1-diMethyl-2-oxoethoxy]iMino]acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]pyridiniuM Inner Salt
CAS 102772-66-7

CeftazidiMe t-Butyl Ester - Physico-chemical Properties

Molecular FormulaC26H30N6O7S2
Molar Mass602.6824
Melting Point>195°C (dec.)
Solubility DMSO (Slightly), Methanol (Slightly)
AppearanceSolid
ColorOff-Whte to Brown
Storage ConditionHygroscopic, -20°C Freezer, Under inert atmosphere

CeftazidiMe t-Butyl Ester - Reference Information

introduction the impurity most likely to be generated in the preparation process of ceftazidime is a trace amount of the impurity in the process of synthesizing ceftazidime tert-butyl ester or ceftazidime active ester raw material.
preparation a preparation method of ceftazidime tert-butyl ester: add 520ml of chloroform and 30ml of tert-butanol into a clean and dry four-port reaction bottle, and cool down to 0-5 ℃. Add 7-APCA70g and tadine active ester 105g, control the temperature and drop triethylamine, and adjust the PH to 7.0-9.0. The temperature is controlled at 0-10 ℃ for 20-24 hours. After the reaction, add 150ml of pure water, stir for 1-2 hours, and separate chloroform. Dropping isopropanol into the liquid medicine to precipitate ceftazidime tert-butyl ester, stirring at 0-10 ℃ for 2 hours. Filter by suction, wash with isopropanol, and dry to obtain dry ceftazidime tert-butyl ester. Weight yield: 145%, purity 98.9%.
Last Update：2024-04-09 15:16:35
CeftazidiMe t-Butyl Ester
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CAS: 102772-66-7
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CAS: 102772-66-7
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Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: Ceftazidime t-Butyl Ester Visit Supplier Webpage Request for quotation
CAS: 102772-66-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Ceftazidime t-Butyl Ester Visit Supplier Webpage Request for quotation
CAS: 102772-66-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
CeftazidiMe t-Butyl Ester
ALPHA-ETHYLPYRIDINE
triacetyl-beta-cyclodextrin
O-NITROPHENYLSULFENYL-1-THIO-BETA-D-GALACTOPYRANOSIDE
quaternariolpc
HARPAGOSIDE
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